Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 4;12(4):878. doi: 10.3390/cancers12040878

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Impact of PF-477736 on cell cycle and homologous recombination repair (HRR) in rucaparib-treated cells. Cells were exposed for 24 h to DMSO, rucaparib, or rucaparib with PF-477736 at the indicated concentrations. (a) Cell cycle analysis of V-C8.B2 cells; data are from a single experiment. (b) Representative images are shown above quantified γH2AX and RAD51 foci, where each data point represents a single nucleus. RAD51 foci were only counted in cells with >mean γH2AX foci in untreated cells. Data are pooled from three independent experiments.

Impact of PF-477736 on cell cycle and homologous recombination repair (HRR) in rucaparib-treated cells. Cells were exposed for 24 h to DMSO, rucaparib, or rucaparib with PF-477736 at the indicated concentrations. (a) Cell cycle analysis of V-C8.B2 cells; data are from a single experiment. (b) Representative images are shown above quantified γH2AX and RAD51 foci, where each data point represents a single nucleus. RAD51 foci were only counted in cells with >mean γH2AX foci in untreated cells. Data are pooled from three independent experiments.