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. 2020 Mar 31;12(4):841. doi: 10.3390/cancers12040841

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Upregulation of DDR1 and co-localization of DDR1 and PDPN in the invasion front of OSCC tissues with angiolymphatic invasion (ALI). (a) Heat map shows top 100 genes differentially expressed in ALI-Yes (n = 18) and ALI-No (n = 22). Expression values of high, moderate, low, and lowest are represented as red, pink, light blue, and dark blue, respectively [32]. DDR1, COL4A6, PDPN, and MMP7 are marked with orange dots. (b) Enriched gene ontology terms (left panel, FDR < 0.05) and selected differentially expressed genes (right panel, fold change > 1.5) in ALI. COL4A5, COL4A6, DDR1, MMP7 and PDPN are denoted with orange dots. (c) Representative immunohistochemistry images of OSCC tissues stained for DDR1 (brown) and PDPN (green). Scale bars, 50 μm.