Figure 44.

(a) The relative luciferase activity of HEK293 cells transfected with various amino acid surface modified G5; PAMAM dendrimers at their optimal N/P ratios for 24 h. Each data point represents mean ± standard deviation (n = 3), statistically significant differences analyzed by students’ t-test are denoted by *p < 0.05 and **p < 0.01, ns represents non-statistical significance. (b) The cellular uptake efficacy of dendrimer polyplexes derived from the various amino acid surface modified G5; PAMAM dendrimers. The polyplexes were labeled with YOOYO-1 and the cellular uptake experiments were conducted on HEK293 cells for 6 hrs. Each data point represents the mean ± standard deviation (n = 3), statistically significant differences are denoted by **p < 0.01. Reprinted with permission from [94]. Copyright 2016 Elsevier.