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. 2020 Mar 27;12(4):803. doi: 10.3390/cancers12040803

Figure 1.

Figure 1

Induced expression of pro-IL-1β in H. pylori-infected THP1 monocytes. The first signal of NLRP3 inflammasome activation requires the optimal production of inflammasome components including pro-IL-1β, which is not generally expressed in immune cells without induction. Different wild-type strains including type-I and type-II H. pylori were infected for 6 h to analyze the pro-IL-1β expression and secretion (A). Furthermore, H. pylori P12 wild-type and isogenic mutants were also used to identify the effect on secretion at 24 h of infection with THP1 monocytes (B). GAPDH protein immunoblots were used as loading reference. ** p ≤ 0.01.