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. 2020 Apr 5;10(4):556. doi: 10.3390/biom10040556

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Weight gain (grams) among various groups of rats that received treatment (A) orally and (B) topically over 12 weeks of the experimental period. NO: Normal rats with oral vehicle treatment, DVO: Diabetic rats with oral vehicle treatment, DTO: Diabetic rats with oral TRF treatment, n = 6, * p < 0.05 versus NO or NE; # p < 0.05 versus DVO. NE: Normal rats with topical vehicle treatment, DVE: Diabetic rats with topical vehicle treatment, DTE: Diabetic rats with topical TRF treatment, n = 6.