Table 2.
Allele and genotype frequencies of CXCR1 and CXCR2 SNPs in patients with gout arthritis and controls
| Allele/genotype | GA (n = 412) n (%) | Control (n = 508) n (%) | c2 | p-value | OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|---|---|---|---|
| rs2234671 | ||||||
| GGReference | 332 (80.6) | 409 (80.5) | — | — | 1.0 | 1.0 |
| GC | 77 (18.7) | 95 (18.7) | 0.000 | 0.993 | 1.00 (0.72-1.39) | 1.06 (0.72-1.57) |
| CC | 3 (0.7) | 4 (0.8) | 0.000 | 1.000 | 0.92 (0.21-4.16) | 2.09 (0.37-11.69) |
| HWE* | χ2 = 0.412 p = 0.814 | χ2 = 0.354 p = 0.838 | ||||
| GReference | 741 (89.9) | 913 (89.9) | — | — | 1.0 | |
| C | 83 (10.1) | 103 (10.1) | 0.002 | 0.963 | 0.99 (0.73-1.35) | |
| rs1126579 | ||||||
| TTReference | 133 (32.3) | 190 (37.4) | — | — | 1.0 | 1.0 |
| TC | 201 (48.8) | 235 (46.3) | 1.826 | 0.177 | 1.22 (0.91-1.63) | 1.33 (0.94-1.87) |
| CC | 78 (18.9) | 83 (16.3) | 2.310 | 0.129 | 1.34 (0.92-1.96) | 1.41 (0.89-2.21) |
| HWE* | χ2 = 0.018 p = 0.991 | χ2 = 0.515 p = 0.773 | ||||
| TReference | 467 (56.7) | 615 (60.5) | — | — | 1.0 | |
| C | 357 (43.3) | 401 (39.5) | 2.794 | 0.095 | 1.17 (0.97-1.41) | |
| rs2230054 | ||||||
| CCReference | 361 (87.6) | 407 (80.1) | — | — | 1.0 | 1.0 |
| CT | 50 (12.1) | 99 (19.5) | 9.125 | 0.003 | 0.57 (0.39-0.82) | 0.50 (0.32-0.77) |
| TT | 1 (0.3) | 2 (0.4) | 0.000 | 1.000 | 0.56 (0.05-6.24) | 0.02 (0.001-0.52) |
| HWE | χ2 = 0.285 p = 0.867 | χ2 = 0.461 p = 0.292 | ||||
| CCReference | 361 (87.6) | 407 (80.1) | ||||
| CT + TT | 51 (12.4) | 101 (19.9) | 9.286 | 0.002 | 0.57 (0.40-0.82) | 0.47 (0.31-0.74) |
| CReference | 772 (93.7) | 913 (89.9) | — | — | 1.0 | |
| T | 52 (6.3) | 103 (10.1) | 8.639 | 0.003 | 0.60 (0.42-0.85) |
*
HWE – Hardy-Weinberg equilibrium