. 2020 Apr 11;12(4):952. doi: 10.3390/cancers12040952

Table 2.

NK cell inhibitory receptors and their ligands [56,57,58].

Human Receptor	Classical MHC Ligands
KIR2DL1	HLA-C group 2 molecules (Asn77 and Lys80) [45]
KIR2DL2	HLA-B and HLA-C group 1 molecules (Ser77 and Asn80) [45]
KIR2DL3	HLA-C group 1 molecules (Ser77 and Asn80) [45] and some HLA-CGroup 2 and HLA-B (weaker affinity than 2DL2) [46]
KIR2DL5(A+B)	unknown
KIR3DL1	HLA-A and B with the Bw4 epitope, amino acid positions 77–83 [45]
KIR3DL2	Some HLA-A allotypes [45]
KIR3DL3	Unknown
LILRB1	HLA-C [48,49]
Human receptor	Non-classical MHC ligands
CD94/NKG2A/B	HLA-E [59,60]
LILRB1	HLA-E and HLA-G [61] and UL18 (MHC viral homologue) [62,63]
Human receptor	Non-MHC-I ligands
SIGLEG-7/9	α2,3- and α2,6-linked sialylated proteins [64,65,66]
NKRP1A	LLT1 (CLEC2D) [67,68]
Mouse	Classical MHC ligands
Ly49A	H2-D^d [11,69,70,71,72,73,74], H2-D^k [74], H2-L^d, H2-K^b, H2-K^b and H2-D^p [69]
Ly49B	Unknown
Ly49C	H2-K^b [74,75], H2-K^d [74], H2-K^k, H2-D^b, H2-D^d [76]
Ly49F	H2-D^d [76]
Ly49G	H2-D^b [69]
Ly49I	H2-K^b [75] and H2-K^d [74]
Human receptor	Non-classical MHC ligands
Ly49A	H2-M3 [77]
Ly49C	H2-Q10 [78]
CD94/NKG2A/B	Qa-1 [59,60]
Human receptor	Non-MHC-I ligands
NKRP1B	Clr-b (Clec2d) [79]
gp49B1	integrin αVβ3 [80]
Ly49E	urokinase plasminogen activator (uPA) [81]
Shared receptors	Non-MHC-I ligands
TIGIT	poliovirus receptor (CD155, PVR) and nectin-2 (CD112, PVRL2) [82,83]
TACTILE	poliovirus receptor (CD155, PVR) and nectin-2 (CD112, PVRL2) [82,83]
CEACAM1	CEACAM1 [84]
LAIR-1	Collagen [85]
KLRG1	E- and N-Cadherin [86,87]
TAMs	Gas6 and Pros1 [88,89]