Table 3.

Inhibitory NK cell receptors and their signaling motifs.

Human	Form	Signaling Motif 1		pY 2 Position	Reference
KIR2DL1	Monomer	2× ITIM	VTYTQL	Y302	[44]
			IVYTEL	Y332
KIR2DL2	Monomer	2× ITIM	VTYTQL	Y302	[44]
			IVYAEL	Y332
KIR2DL3	Monomer	2× ITIM	VTYAQL	Y303	[44]
			IVYTEL	Y333
KIR2DL5	Monomer	2× ITIM	VTYAQL	Y298	[44]
			TMYMEL	Y228
KIR3DL1	Monomer	2× ITIM	VTYAQL	Y398	[44]
			ILYTEL	Y428
KIR3DL2	Monomer	2× ITIM	VTYAQL	Y398	[44]
			SVYTEL	Y428
KIR3DL3	Homodimer	1× ITIM	VTYAQL	Y381	[44,139]
LILRB1/ILT2	Monomer	4× ITIM	NLYAAV	Y533	[50,51,140]
			VTYAEV	Y562
			VTYAQL	Y614
			SIYATL	Y644
SIGLEC-7/9	Monomer	1× ITIM	IQYAPL/LQYASL	Y437/Y433	[131,132]
		1× ITIM	NEYSEI/TEYSEI	Y460/Y456
NKRP1A	Homodimer	1× ITIM-like	AIYAEL	Y7	[141]
Mouse
Ly49A	Homodimer	1× ITIM	VTYSMV	Y8	[93,142]
Ly49B	Homodimer	1× ITIM	VTYTTL	Y8	[93,142]
Ly49C, E-I	Homodimer	1× ITIM	VTYSTL	Y8	[93,142]
NKRP1B	Homodimer	ITIM	LVYADL	Y8	[141]
Shared
iNKG2A/B	Heterodimer with CD94	2× ITIM	(h) VIYSDL	Y8	[95,96]
			(m) VTYAEL
		1× ITIM	(h) EITYAEL	Y40	[95,96]
		1× ITIM-like	(m) IIYSDF
TIGIT	Monomer	1× ITT-like	YFN	(h) Y225	[82,83]
				(m) Y230
		1× ITIM	LSYRSL	(h) Y231
				(m) Y236
TACTILE	Monomer	1× ITIM	IKYTCI	(h) Y566	[105]
				(m) Y583
		1× YxxM	(h) YHEM	(h) Y579
CEACAM1	Homomer Homodimer Oligomer	(h) 2× ITIM	VTYSTL	Y459	[84,143,144]
			IIYSEV	Y486
		(m) 1× ITIM	VAYTVL	Y454
		(m) 1× ITSM	TVYSEV	Y481
LAIR-1	Monomer	2× ITIM	(h) VTYAQL	Y251	[145]
			(h) ITYAAV	Y281
			(m) VTYIQL	Y228
			(m) STYAAI	Y257
KLGR1	Homodimer	1× ITIM	(h) VIYSML	Y7	[146,147]
			(m) SIYSTL
Shared	Form	Signaling Motif 1		pY 2 Position	Reference
Tyro	Homodimer Heterodimer	1× ITIM-like	IYNYL	(h) Y742 (m) Y744	[148]
Axl	Homodimer Heterodimer	1× ITIM	LLYSRL	(h) Y634 (m) Y628	[148]
		1× ITIM-like	IYDYL	(h) Y759/761 (m) Y753/755
Mer	Homodimer Heterodimer	1× ITIM	LLYSRL	(h) Y685 (m) Y680	[148]
		1× ITIM-like	MYDYL	(h) Y810/Y812 (m) Y805/807

¹ m = mouse, h = human; ² Phosphorylated tyrosine (pY).