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. 2020 Apr 10;12(4):939. doi: 10.3390/cancers12040939

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Biomarkers of spleen colonization. Changes in protein abundances in the spleen tissue of rats with M5-T1 mesothelioma (Tumor) in comparison with control rats (Control). (A) Eight potential biomarkers showing significant differences. Proteins detected in the spleen from the 39 proteins listed in Table 2. (B) Other S100 proteins detected in spleen. (C) Evolution of the eight biomarkers plus S100A9 according to the stage of M5-T1 mesothelioma development. “Early” and “Advanced” correspond to the spleens of tumor-bearing rats. Blank bars correspond to the absence of significant differences between groups.