Table 1.
Classification of the biocollection of rat mesothelial cell lines. Roulois et al. [18] showed photographs of each cell line at confluence and their growth characteristics (Supplementary Figure S2 and Table S1, respectively).
| Category | Group | Subgroup | Name | Differential Gene Expression |
|---|---|---|---|---|
|
Preneoplastic
(PN) |
Epithelioid morphology (PN-[Epith]) C1 |
Subnormal (Sbnl) |
F1-0e | Pdpnhigh Ezrhigh Cdh1high Acta2low Mychigh Igf1low TGFb1low Il10low |
| F1-0f | ||||
| M2-0 | ||||
| Preneoplastic epithelioid (PNep) |
F2-0 | Pdpnhigh Ezrhigh Cdh1med Acta2low Myclow Igf1high TGFb1low Il10high | ||
| F2-3 | ||||
| F2-4 | ||||
| F3-1 | ||||
| M3-1 | ||||
| Preneoplastic intermediary (PNint) |
F1-2 | Pdpnhigh Ezrhigh Cdh1med Acta2med TGFb1high Il10low | ||
| F5-2 | ||||
|
Sarcomatoid morphology (PNsarc) C2 |
Sarcomatoid hypoxia low (PNsarc1) |
F1-1 | Cdh1low Acta2high Tgfb1high Zebhigh Hif1alow CCl7low Vegfalow | |
| F2-2 | ||||
| M2-1 | ||||
| M3-2 | ||||
| Sarcomatoid hypoxia high (PNsarc2) |
F1-3 | Cdh1low Acta2high Tgfb1high Zebhigh Hif1ahigh CCl7high Vegfahigh | ||
| F2-1 | ||||
| F5-3 | ||||
| M1-1 | ||||
| M2-3 | ||||
| Miscellaneous (PNmisc) |
M2-2 | Acta2med Ezrmed Tgfb1high | ||
| M4-1 | ||||
| F2-5 | ||||
| F3-2 | ||||
|
Neoplastic
(N) C3 |
Non-invasive C5 |
M5-T2 | Cdkn2alow Lgals3high Vegfahigh | |
| Invasive C4 |
F4-T2 | Cdkn2alow Lgals3high Vegfalow | ||
| F5-T1 | ||||
| M5-T1 | ||||