Table 3.
PathwayConnector—complementary pathway networks by HOMA-IR interactome.
| S. No | Pathway | p Value | Common Pathways | Common Genes | Genes Found | Pathway Ratio | Rank |
|---|---|---|---|---|---|---|---|
| 1 | Proteoglycans in cancer | 4.932838 × 10−13 | 14/4246 | 10/201 | 10/32 | 3.297 × 10−3 | 1 |
| 2 | Glioma | 8.665005 × 10−12 | 8/4246 | 7/75 | 7/32 | 1.884 × 10−3 | 2 |
| 3 | Pathways in cancer | 1.556996 × 10−7 | 23/4246 | 9/526 | 9/32 | 5.417 × 10−3 | 10 |
| 4 | MicroRNAs in cancer | 1.661089 × 10−8 | 7/4246 | 8/299 | 8/32 | 1.649 × 10−3 | 5 |
| 5 | FoxO signaling pathway | 1.437119 × 10− 9 | 13/4246 | 7/132 | 7/32 | 3.062 × 10−3 | 3 |
| 6 | mTOR signaling pathway | 2.470845 × 10−6 | 8/4246 | 7/153 | 7/32 | 1.884 × 10−3 | 18 |
| 7 | HIF-1 signaling pathway | 1.30885 × 10−8 | 9/4246 | 6/100 | 6/32 | 2.120 × 10−3 | 4 |
| 8 | PI3K-Akt signaling pathway | 9.186771 × 10−7 | 17/4246 | 7/354 | 7/32 | 4.004 × 10−3 | 14 |
| 9 | Neurotrophin signaling pathway | 3.280781 × 10−8 | 6/4246 | 6/119 | 6/32 | 1.413 × 10−3 | 6 |
| 10 | Longevity regulating pathway | 3.751219 × 10−7 | 8/4246 | 5/62 | 5/32 | 1.884 × 10−3 | 7 |
| 11 | Melanoma | 9.131152 × 10−8 | 7/4246 | 5/72 | 5/32 | 1.649 × 10−13 | 8 |
| 12 | Bacterial invasion of epithelial cells | 1.468947 × 10−7 | 7/4246 | 5/74 | 5/32 | 1.649 × 10−3 | 9 |
| 13 | EGFR tyrosine kinase inhibitor resistance | - | 10/4246 | 5/79 | 5/32 | 2.355 × 10−3 | new |
| 14 | Focal adhesion | 7.174111 × 10−7 | 9/4246 | 6/199 | 6/32 | 2.120 × 10−3 | 13 |
| 15 | Longevity regulating pathway | 5.389533 × 10−8 | 9/4246 | 5/89 | 5/32 | 2.120 × 10−3 | 12 |
| 16 | Prostate cancer | 2.852625 × 10−7 | 9/4246 | 5/97 | 5/32 | 2.120 × 10−3 | 11 |
| 17 | Leukocyte transendothelial migration | 1.163798 × 10−6 | 3/4246 | 5/112 | 5/32 | 7.065 × 10−4 | 15 |
| 18 | ErbB signaling pathway | 1.1 × 10−5 | 10/4246 | 4/85 | 4/32 | 2.355 × 10−3 | 20 |
| 19 | Small cell lung cancer | 0.000348 | 7/4246 | 4/93 | 4/32 | 1.649 × 10−3 | 37 |
| 20 | Non-small cell lung cancer | 0.003619 | 8/4246 | 3/66 | 3/32 | 1.884 × 10−3 | 57 |
| 21 | MAPK signaling pathway | 0.062537 | 7/4246 | 4/295 | 4/32 | 1.649 × 10−3 | 96 |
| 22 | p53 signaling pathway | 0.000181 | 4/4246 | 3/72 | 3/32 | 9.421 × 10−4 | 31 |
| 23 | Colorectal cancer | 0.004417 | 10/4246 | 3/86 | 3/32 | 2.355 × 10−3 | 61 |
| 24 | Fluid shear stress and atherosclerosis | 9/4246 | 3/139 | 3/32 | 2.120 × 10−3 | new | |
| 25 | Cell cycle | 0.016751 | 4/4246 | 2/124 | 2/32 | 9.421 × 10−4 | 81 |
| 26 | Apoptosis | 0.021037 | 9/4246 | 2/136 | 2/32 | 2.120 × 10−3 | 87 |
| 27 | Chemokine signaling pathway | 0.035898 | 7/4246 | 2/190 | 2/32 | 1.649 × 10−3 | 94 |