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Antidepressant activity of MEHC on forced swimming (A) and tail suspension (B) tests in mice. Results are expressed in mean ± S.E.M. (* p < 0.05) and (** p < 0.01), significantly different from control; ANOVA followed by Dunnett’s test (n = 6, per group). MEHC: methanol extract of Holigarna caustica leaves; HC 200, methanol extract of H. caustica 200 mg/kg; HC 400, methanol extract of H. caustica 400 mg/kg; Reference drug imipramine hydrochloride (10 mg/kg).
