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. 2020 Mar 27;9(4):810. doi: 10.3390/cells9040810

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The p53-related miRNAs controls the osteoblastic differentiation through interplay with Notch, Wnt/β-catenin, and Sonic/Hedgehog (HH) pathways. AP-1: Activator protein-1; β-cat: β-catenin; DKK-1: Dickkopf Wnt signaling pathway inhibitor 1; FOXO: Forkhead transcription factor; HES-1: Hairy/enhancer f split; HEY-1: Hes-related protein; HH: Sonic/Hedgehog; IL: interleukin; Lef1: lymphoid enhancer-binding factor 1; MDM2: mouse double minute 2 homologue; RUNX2: runt-related transcription factor 2; Ptch: Patched receptor; Smo: Smoothened; VEGFA: Vascular endothelial growth factor A.