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. 2020 Mar 25;10(4):497. doi: 10.3390/biom10040497

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CSF ubiquitin levels in neurodegenerative dementias and in prion disease spectrum. (A) CSF ubiquitin levels in prion disease (PRION), Alzheimer’s disease (AD), frontotemporal dementia (FTD) and controls. (B) Sporadic Creutzfeldt–Jakob disease (sCJD) VV2 showed significantly higher levels of CSF ubiquitin compared to MM(V)1 and MV2K types. (C) CSF ubiquitin in genetic prion disease cases (genetic (g)CJD E200K, gCJD V210I and fatal familial insomnia (FFI)). (D) CSF ubiquitin levels increased through disease stages in prion disease. Horizontal lines represent medians. CSF ubiquitin levels are expressed in logarithmic scale. Only statistically significant differences are displayed (Kruskal–Wallis test followed by Dunn–Bonferroni post hoc test).