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. 2020 Mar 25;12(4):778. doi: 10.3390/cancers12040778

Figure 1.

Figure 1

Expression of Hippo-Yes-associated protein 1 (YAP1) signaling pathway-related proteins in gallbladder cancer (GBC) patients. Representative immunohistochemistry images and results of staining scores (immunoscore) in chronic cholecystitis and advanced cancer cases (cytoplasmic and nuclear staining scores): (A) YAP1; (B) TAZ; (C) MST1 protein expression in chronic cholecystitis and in a well differentiated pT2 advanced cancer. Red arrows indicated the patchy staining pattern in YAP1. Scale bar in immunohistochemistry assays: 40 µm. The immunoscores are represented as median with rank (*** p < 0.001 by Wilcoxon–Mann–Whitney U-Test).