Figure 2.

Nuclear expression of YAP1 in GBC is the second most important prognostic factor after depth of invasion in patients with subserosal infiltration (pT2). (A) GBC patient survival rates by tumor infiltration. Subserosal infiltration had an intermediate prognostic value (median survival 19.9 months) by univariate analysis; (B) Subserosal gallbladder cancer patient survival rates by high and low YAP1 nuclear expression. Patients with subserosal GBC and high nuclear YAP1 had a median survival of 8.0 months compared to patients with subserosal GBC and low nuclear YAP1, which have undefined survival by multiple correlation analyses. MS: Median survival; HR: Hazard ratio. 95% Confidence interval (0.80–1.86 months).