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. 2020 Mar 31;12(4):843. doi: 10.3390/cancers12040843

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Plasma overexpressed miRNAs as key modulators of drug resistance observed to be altered in the cases of the analysis of colorectal and rectal cancer chemo-treated versus untreated. (A) Venn diagram for the altered miRNAs which are supposed to interfere with drug resistance in the analyzed groups. (B) Heatmap generated using DIANA-miRPath v3.0 (http://snf-515788.vm.okeanos.grnet.gr), showing miR-21-5p, miR-34a-3p, miR-126-3p, miR-20a-5p, miR-106-5p, miR-17-5p and miR-93-5p targets associated with biological processes. (C) miRNET network for common miRNA signatures emphasizing an important number of target genes related to pathways in cancer and TP53 signaling.