Table 4.
Top 15 most upregulated and downregulated plasma microRNAs.
| Colon Cancer versus Healthy Patients | Rectal Cancer versus Healthy Patients | Colorectal Cancer versus Healthy Patients | ||||||
|---|---|---|---|---|---|---|---|---|
| Systematic Name | FC (abs) | p (Corr) | Systematic Name | FC (abs) | p (Corr) | Systematic Name | FC (abs) | p (Corr) |
| miR-195-5p | −20.10 | 2.23 × 10−15 | miR-4530 | −28.78 | 2.59 × 10−6 | miR-4741 | −19.07 | 2.57 × 10−12 |
| miR-363-3p | −19.81 | 3.28 × 10−7 | miR-6850-5p | −27.90 | 1.04 × 10−5 | miR-642b-3p | −18.98 | 4.89 × 10−10 |
| miR-96-5p | −18.73 | 1.14 × 10−18 | miR-642b-3p | −26.12 | 6.43E × 10−11 | miR-195-5p | −16.93 | 2.50 × 10−16 |
| miR-4741 | −14.42 | 8.34 × 10−8 | miR-5787 | −24.89 | 2.93 × 10−5 | miR-134-5p | −15.94 | 1.57 × 10−12 |
| miR-374a-5p | −13.10 | 1.69 × 10−7 | miR-5703 | −23.46 | 7.31 × 10−5 | miR-5787 | −14.36 | 1.37 × 10−4 |
| miR-660-5p | −12.87 | 7.03× 10−8 | miR-4741 | −22.70 | 7.13 × 10−11 | miR-96-5p | −14.27 | 1.88 × 10−16 |
| miR-192-5p | −12.86 | 3.82 × 10−9 | miR-642a-3p | −22.42 | 1.47 × 10−14 | miR-4530 | −14.15 | 1.03 × 10−4 |
| miR-642b-3p | −12.62 | 7.01 × 10−6 | miR-8072 | −21.87 | 1.21 × 10−11 | miR-6791-5p | −13.44 | 5.09 × 10−6 |
| miR-151a-5p | −11.83 | 1.20 × 10−7 | miR-134-5p | −21.86 | 4.62 × 10−15 | miR-4534 | −13.13 | 6.24 × 10−6 |
| miR-301a-3p | −11.82 | 1.45 × 10−9 | miR-630 | −21.33 | 1.12× 10−4 | miR-6850-5p | −13.03 | 3.22 × 10−4 |
| miR-30b-5p | −11.08 | 3.17 × 10−6 | miR-6791-5p | −19.38 | 1.73× 10−7 | miR-6068 | −13.01 | 2.25 × 10−7 |
| miR-134-5p | −10.93 | 8.58 × 10−7 | miR-3663-3p | −18.29 | 5.84 × 10−6 | miR-6728-5p | −12.91 | 2.24 × 10−13 |
| miR-18a-5p | −10.83 | 2.55 × 10−8 | miR-4534 | −18.28 | 1.64 × 10−6 | miR-363-3p | −12.63 | 7.60 × 10−6 |
| miR-126-5p | −10.81 | 5.37 × 10−9 | miR-6728-5p | −18.07 | 2.15 × 10−18 | miR-642a-3p | −11.93 | 7.58 × 10−4 |
| miR-425-5p | −10.58 | 5.28 × 10−5 | miR-1227-5p | −17.65 | 2.65 × 10−14 | miR-8072 | −11.71 | 1.13 × 10−6 |
| miR-1228-3p | 27.70 | 6.85 × 10−9 | miR-1228-3p | 38.80 | 1.22 × 10−11 | miR-1228-3p | 33.80 | 1.03 × 10−13 |
| miR-4730 | 25.41 | 1.61 × 10−12 | miR-1238-3p | 36.44 | 2.04 × 10−11 | miR-1238-3p | 30.58 | 6.37 × 10−13 |
| miR-6716-3p | 24.99 | 6.11 × 10−12 | miR-6508-5p | 35.56 | 4.22 × 10−10 | miR-6069 | 30.11 | 2.96 × 10−13 |
| miR-6069 | 24.44 | 1.15 × 10−8 | miR-6737-3p | 34.81 | 4.06 × 10−12 | miR-6800-3p | 29.83 | 2.08 × 10−11 |
| miR-6800-3p | 24.09 | 6.46 × 10−8 | miR-6069 | 34.58 | 4.03 × 10−11 | miR-6508-5p | 29.39 | 1.6 0 × 10−11 |
| miR-1238-3p | 23.90 | 2.31 × 10−8 | miR-1234-3p | 34.11 | 7.48 × 10−13 | miR-6737-3p | 28.55 | 5.39 × 10−14 |
| miR-6737-3p | 21.77 | 7.00 × 10−9 | miR-6800-3p | 34.04 | 9.46 × 10−10 | miR-6716-3p | 27.72 | 3.38 × 10−17 |
| miR-6508-5p | 21.64 | 9.66 × 10−8 | miR-191-3p | 33.43 | 2.20 × 10−11 | miR-4730 | 25.70 | 5.06 × 10−14 |
| miR-451b | 20.37 | 1.71 × 10−7 | miR-6716-3p | 28.94 | 1.16 × 10−12 | miR-191-3p | 24.76 | 1.06 × 10−11 |
| miR-5010-3p | 19.00 | 1.32 × 10−7 | miR-3162-3p | 27.82 | 5.99 × 10−17 | miR-451b | 24.16 | 1.81 × 10−10 |
| miR-4433a-5p | 17.96 | 7.84 × 10−9 | miR-4433a-5p | 27.76 | 2.32 × 10−11 | miR-1234-3p | 24.01 | 9.15 × 10−12 |
| miR-191-3p | 17.01 | 2.31 × 10−7 | miR-6797-3p | 27.48 | 1.92 × 10−13 | miR-4433a-5p | 23.76 | 1.55 × 10−13 |
| miR-3162-3p | 16.21 | 3.08 × 10−9 | miR-1281 | 27.26 | 7.17 × 10−14 | miR-316-2-3p | 21.95 | 1.58 × 10−16 |
| miR-1234-3p | 15.44 | 1.04 × 10−6 | miR-451b | 25.66 | 1.06 × 10−8 | miR-6797-3p | 20.71 | 2.22 × 10−13 |
| miR-1281 | 14.80 | 1.69 × 10−7 | miR-1825 | 25.28 | 1.43 × 10−13 | miR-1281 | 20.66 | 3.25 × 10−13 |
bold letters were used for miRNAs selected for qRT-PCR validation.