Figure 5. Viral Phenotypes of Sarm1 CRISPR Knockout Mice.

(A) WT, Sarm1^AD, Sarm1^AGS3, and Sarm1^AGS12 mice were infected intranasally with 10⁷ plaque-forming units (PFUs) of VSV, and survival was measured.

(B) Mice were infected as in (C). Chemokine production in the brain was measured by qPCR at day 6 post-infection.

(C) WT, Sarm1^AD, and Sarm1^AGS3 mice were infected with 10² ffu of WNV-NY99 via footpad injection, and survival was measured.

(D) WT, Sarm1^AD, Sarm1^AGS3, and Sarm1^AGS12 mice were infected intraperitoneally with 10³ PFUs of the original LACV strain, and survival was measured.

(A), (C), and (D) show combined results of 2 experiments with similar results; (B) shows mean ± SD for n = 3 (PBS) and n = 10 (VSV) and is representative of 3 experiments. *p < 0.05, log rank test (A, C, and D) and unpaired t test (B). See also Table S2.