Figure 1.

Serum concentrations after methylprednisolone. Serum concentrations of patients diagnosed with multiple sclerosis according to the McDonald criteria of 2017 and clinically isolated syndrome who converted to multiple sclerosis during follow-up. Each dot represents a single measurement of a patient who was untreated or received intravenous methylprednisolone with the indicated dose. Depicted are serum concentrations of kappa free light chains (KFLC) (A), immunoglobulin type G (IgG) (B), IgA (C), and IgM (D) in untreated patients (n = 42) and patients who received methylprednisolone infusion of 1000 mg (n = 8), 2000 mg (n = 25), 3000 mg (n = 16), 4000 mg (n = 9), or 5000 mg (n = 7). p-values of significant differences are illustrated as asterisks.