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Non-modified MSCs and IL7/IL12 engineered MSCs have a similar pattern of secreted cytokines that is altered in presence of TNF-α and IFN-γ. MSCs of two donors were transduced to secrete IL7 and IL12, respectively, and cultivated for 72 h (25,000/mL) in presence and absence of added TNF-α (10 ng/mL) and IFN-γ (10 ng/mL), respectively. Supernatants were collected and subjected in duplicates to 43-parameter multiplex analysis as described in Materials and Methods.
