Figure 2.

The BMAL1:CLOCK (Aryl Hydrocarbon Receptor Nuclear Translocator Like (AHRNTL aka BMAL):(Circadian Locomotor Output Cycles Protein Kaput)) heterodimer regulates multiple genes involved in fatty acid oxidation (A), lipogenesis, and lipolysis (B). Knockout models involving loss of the circadian proteins PER2, REV-ERBA, and BMAL1 have elucidated the physiological consequences of these activities within the context of white adipose tissue (WAT) and brown adipose tissue (BAT) (also see Table 1). (Curved lines are indicative of rhythmic release.).