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Core clock genes control adipogenesis in both (A) WAT and (B) BAT. In WAT, the core clock regulates genes that repress differentiation (Gilz) or promote the fate of a mature adipocyte (Pparg). Similarly, the CLOCK:BMAL1 regulation of Per3 in APCs can prevent adipogenesis in WAT by the subsequent and direct downregulation Klf15 by PER3 and BMAL1 at the Klf15 locus.
