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. 2020 Apr 2;9(4):863. doi: 10.3390/cells9040863

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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WAT cells as drivers of fibrosis. (A) Tissue remodeling in fibrosis. Pathogenic changes in the epithelium (white) induce the activation and proliferation of fibroblasts in adjacent adipose tissue (AT). (B) AT fibrosis is linked with loss of lipid droplets (orange) in adipocytes, which may convert into myofibroblasts that promote disease. Activated myofibroblasts (red) deposit an extracellular matrix (ECM). Adipose tissue is a key source of cells that convert into myofibroblasts secreting extracellular matrixes (ECMs) and driving fibrosis.