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Selective growth inhibitory activities of SPHK inhibitors in parental and breast CSCs. HCC38 and MDA-MB-468 parental and CSCs were treated with different concentrations of FTY720, PF543, ABC294640, and SK1-II for 72 h, and cell viability was determined by the MTT or MTS assay. Points represent the mean ± s.d. of three independent experiments. Asterisks (*) indicate statistical significance compared with parental cells (p < 0.05, Student’s t-test).
