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. 2020 Mar 31;9(4):843. doi: 10.3390/cells9040843

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hallmarks of the cuprizone model. (A) Schematic drawing illustrating pathological hallmarks during the course of cuprizone-induced demyelination. The blue line illustrates the levels of myelination. (B) The left image illustrates interfascicular oligodendrocytes (arrowheads) in the corpus callosum of a control mouse. The center image illustrates the appearance of an apoptotic cell (arrow) after 1 week of cuprizone intoxication. The right image illustrates mature OLIG2⁺/CC1⁺ oligodendrocytes and pre-mature OLIG2⁺/CC1⁻ oligodendrocytes (white arrowheads). Scale bar = 10 µm. Abbreviations: oligodendrocyte transcription factor 2 (OLIG2), adenomatous polyposis coli gene clone CC1 (CC1).