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Simplified model depicting the role of HspBP1/hsp70 interactions for SG formation. Stress, such as the oxidant DEM, induces SG assembly. HspBP1, through its inhibition of hsp70, controls SG formation. Overexpression of HspBP1 triggers SG assembly, even in the absence of stress. HspBP1 knockdown or HspBP1 mutants with compromised hsp70 interaction impair SG assembly during oxidative stress. See text for details.
