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Model depicting the role of H2A.B in pre-mRNA splicing. Following the replacement of H2A.Z with H2A.B.3 to assemble active chromatin, H2A.B.3 directly recruits RNA processing factors from splicing speckles to an active gene. Upon transcriptional elongation and the synthesis of mRNA, H2A.B.3 binds and “holds” onto this RNA, thus releasing the splicing factors to facilitate the splicing process.
