Table 1.
Baseline characteristics.
| UC (n = 378) | HC (n = 10) | |
|---|---|---|
| Age at Diagnosis in Years | 43 (30–57) | 36 (26–43) |
| Sex | ||
| - Female | 190 (50.3%) | 6 (60%) |
| - Male | 188 (49.7%) | 4 (40%) |
| Extra-Intestinal Manifestations | ||
| - Yes | 46 (12.2%) | - |
| Family History of IBD | ||
| - Yes | 42 (11.1%) | - |
| Duration of Complaints before Diagnosis in Weeks | 10 (4–16) | - |
| Smoking Status at Baseline Endoscopy | ||
| - Ceased | 84 (21.5%) | 0 (0%) |
| - Yes | 48 (12.3%) | 3 (30%) |
| - No or unknown | 246 (66.2%) | 7 (70%) |
| Calprotectin | 322 (167–1161) | - |
| Mayo Endoscopic Score | ||
| - Mayo 0 | - | 10 (100%) |
| - Mayo 1 | 156 (41.3%) | 0 (0%) |
| - Mayo 2 | 174 (46.0%) | 0 (0%) |
| - Mayo 3 | 48 (12.7%) | 0 (0%) |
| UC Localization | ||
| - Extent | ||
| ○ E1: Ulcerative proctitis | 136 (36.0%) | - |
| ○ E2: Left-sided UC | 149 (39.4%) | |
| ○ E3: Extensive UC | 93 (24.6%) | |
| Histological Inflammation Geboes Score | ||
| - ≥ 0.1 and < 3.1 | 2 (0.5%) | 10 (100%) |
| - ≥ 3.1 | 376 (99.5%) | 0 (0%) |
| Location Biopsies Taken at Baseline Endoscopy | ||
| - Rectum | 143 (37.8%) | - |
| - Sigmoid | 152 (40.2%) | - |
| - Right-sided | 2 (0.5%) | - |
| - Left- and right-sided | 81 (21.4%) | 10 (100%) |
| Effective Remission Induction Treatment at Diagnosis | ||
| - No treatment | 9 (2.4%) | 10 (100%) |
| - 5-ASA | 223 (59.0%) | - |
| - Topical steroids | 42 (11.1%) | - |
| - Oral steroids | 86 (22.8%) | - |
| - Anti-TNF | 15 (4.0%) | - |
| - Resective surgery | 3 (0.8%) | - |
Values expressed in n (%) or as median with interquartile range; HC, Healthy control; IBD, Inflammatory Bowel Diseases; IQR, Interquartile range; UC, ulcerative colitis.