Table 2.
The presence of follicles and extrafollicular PNAd+, MAdCAM-1+ and/or ERG+ venules in the inflamed colonic biopsies at UC diagnosis compared to healthy controls.
| UC (Inflamed) n = 378 |
HC (Non-Inflamed) N = 10 |
P-Value | |
|---|---|---|---|
| Total Surface of the Biopsy in mm2 | 2.3 (1.8–3.0) | 2.1 (1.6–3.1) | 0.62 |
| Total Follicular Surface in mm2 | 0.15 (0.05–0.32) | 0.04 (0.0–0.09) | 0.004 |
| Total Extra Follicular Surface in mm2 | 2.0 (1.5–2.7) | 2.0 (1.6–3.1) | 0.93 |
| Follicles | |||
| - Absolute number | 3.0 (1.0–5.0) | 1.0 (0.0–1.0) | 0.001 |
| - Number per mm2 | 1.3 (0.7–2.1) | 0.04 (0.0–0.09) | 0.001 |
| Extrafollicular ERG+ Venules | |||
| - Absolute number | 366 (263–485) | 206 (162–244) | 0.001 |
| - Number per mm2 (density) | 159 (130–193) | 108 (66–116) | 0.001 |
| Extrafollicular PNAd+Venules | |||
| - Absolute number | 17.5 (6.0–34.0) | 0.0 (0.0–0.0) | 0.001 |
| - Number per mm2 (density) | 7.7 (2.6–14.0) | 0.0 (0.0–0.0) | 0.001 |
| - As % of ERG+ venules (proportion) | 4.9 (2.0–8.3) | 0.0 (0.0–0.0) | 0.001 |
| Absolute Number of Intrafollicular PNAd+ Venules | 1.0 (0.0–4.0) | 0.0 (0.0–0.0) | 0.008 |
| Extrafollicular MAdCAM-1+Venules | |||
| - Absolute number | 19.0 (8.0–36.0) | 1.5 (0.0–8.8) | 0.001 |
| - Number per mm2 (density) | 9.1 (3.8–15.6) | 0.5 (0.0–3.9) | 0.001 |
| - As % of ERG+ venules (proportion) | 5.8 (2.5–9.9) | 0.8 (0.0–3.8) | 0.001 |
| Absolute Number of Intrafollicular MAdCAM-1+ Venules | 0.0 (0.0–3.0) | 0.0 (0.0–1.5) | 0.19 |
| Extrafollicular MAdCAM-1+ PNAd+Venules | |||
| - Absolute number | 6 (1.0–15.0) | 0 (0–0) | 0.001 |
| - Number per mm2 (density) | 2.4 (0.6–6.0) | 0 (0–0) | 0.001 |
| - As % of ERG+ venules (proportion) | 1.6 (0.4–3.7) | 0 (0–0) | 0.001 |
| Percentage MAdCAM-1+ of PNAd+ Venules | 42.9 (18.1–70) | * | - |