Table 3.
The presence of follicles and (PNAd+, MAdCAM-1+, ERG+) venules in inflamed and non-inflamed colonic biopsies of UC patients at follow-up endoscopy.
| UC Patients in Remission at Follow-Up n = 93 |
UC Patients with Active Disease at Follow-Up n = 285 |
||||||
|---|---|---|---|---|---|---|---|
| Baseline | Follow-up | P-Value | Baseline | Follow-up | P-value | P-value | |
| Inflamed | Non-Inflamed | Inflamed | Inflamed | Follow-Up Non-Inflamed vs Inflamed | |||
| Total Surface of the Biopsy in mm2 | 2.4 (1.7–3.2) | 2.0 (1.5–2.7) | 0.1 | 2.3 (1.8–2.9) | 2.2 (1.7–2.8) | 0.21 | 0.39 |
| Total Follicular Surface in mm2 | 0.12 (0.03–0.3) | 0.03 (0.0–0.1) | 0.001 | 0.16 (0.06–0.34) | 0.1 (0.04–0.3) | 0.001 | 0.001 |
| Total Extra Follicular Surface in mm2 | 2.1 (1.5–3.0) | 2.0 (1.5–2.6) | 0.43 | 2.0 (1.6–2.6) | 2.0 (1.6–2.6) | 0.92 | 0.6 |
| Follicles | |||||||
| - Absolute number | 2 (1–4) | 1 (0–1) | 0.001 | 3 (1–5) | 2 (1–4) | 0.001 | 0.001 |
| - Number per mm2 | 1.1 (0.5–1.9) | 0.4 (0.0–0.7) | 0.001 | 1.4 (0.7–2.2) | 1.1 (0.5–1.8) | 0.001 | 0.001 |
| ERG+ Venules | |||||||
| - Absolute number | 336 (232–468) | 235 (164–339) | 0.001 | 371 (274–490) | 394 (292–546) | 0.12 | 0.001 |
| - Number per mm2 (density) | 146 (123–173) | 123 (93–155) | 0.001 | 163 (131–194) | 184 (150–224) | 0.001 | 0.001 |
| Extrafollicular PNAd+ Venules | |||||||
| - Absolute number | 14 (3–34) | 0.0 (0.0–0.8) | 0.001 | 19 (7–35) | 17 (5–32) | 0.39 | 0.001 |
| - Number per mm2 (density) | 6.0 (1.4–11.8) | 0.0 (0.0–0.17) | 0.001 | 8.3 (3.4–14.0) | 7.7 (2.8–14.3) | 0.85 | 0.001 |
| - As % of ERG+ venules (proportion) | 4.3 (1.0–8.6) | 0.0 (0.0–0.08) | 0.001 | 5.3 (2.2–8.3) | 4.0 (1.3–7.8) | 0.04 | 0.001 |
| Absolute number of intrafollicular PNAd+ Venules | 1 (0–3) | 0.0 (0.0–0.0) | 0.001 | 2 (0–5) | 0 (0–3) | 0.003 | 0.001 |
| Extrafollicular MAdCAM-1+ Venules | |||||||
| - Absolute number | 20 (8.5–42.0) | 18 (9.0–32.0) | 0.38 | 18 (8–35) | 32.0 (16.0–52.0) | 0.001 | 0.001 |
| - Number per mm2 (density) | 10.7 (3.6–16.3) | 10.0 (5.1–15.1) | 0.71 | 9.0 (3.8–15.5) | 14.2 (8.4–22.2) | 0.001 | 0.001 |
| - As % of ERG+ venules (proportion) | 6.9 (2.6–11.0) | 7.8 (4.5–11.8) | 0.15 | 5.5 (2.5–9.5) | 7.8 (4.5–12.0) | 0.001 | 0.8 |
| Absolute number of intrafollicular MAdCAM-1+ Venules | 0.0 (0.0–2.0) | 0.0 (0.0–1.0) | 0.02 | 0 (0–3) | 0.0 (0.0–3.0) | 0.37 | 0.002 |
| Extrafollicular MAdCAM-1+ PNAd+ Venules | |||||||
| - Absolute number | 5 (0–11) | 0 (0–0) | 0.001 | 6 (1–15) | 8 (2–17) | 0.04 | 0.001 |
| - Number per mm2 (density) | 2.03 (0.0–4.52) | 0 (0–0) | 0.001 | 2.5 (0.7–6.4) | 3.6 (0.8–7.8) | 0.002 | 0.001 |
| - As % of ERG+ venules (proportion) | 1.4 (0.0–2.7) | 0 (0–0) | 0.001 | 1.8 (0.4–3.8) | 2.0 (0.5–3.9) | 0.21 | 0.001 |
| Percentage MAdCAM-1+ of PNAd+ venules | 48.0 (13.9–69.4) | * | - | 42.9 (19.1–70.5) | 57.9 (35.7–83.3) | 0.001 | - |
Values expressed in n (%) or as median (interquartile range); ERG, ETS related gene; HC, Healthy control; MAdCAM-1, mucosal vascular addressin cell adhesion molecule-1; PNAd, peripheral node addressin; UC, ulcerative colitis. * There are no PNAd+ venules in non-inflamed biopsies, therefore no percentage is presented.