Skip to main content
. 2020 Apr 8;9(4):911. doi: 10.3390/cells9040911

Figure 2.

Figure 2

Aberrant FGFR1 and PARP1 expression is associated with cancer stem cell-like phenotype, regulates DNA repair, and modulates response to therapy in PDAC cells. (A) Oncoprint analysis of FGFR1, PARP1, ALDH1A1, ABCB1, RAD51, and H2AFX genetic alterations in the provisional TCGA pancreatic adenocarcinoma cohort. (B) Expression profile and (C) multidimensional scaling correlation matrix with (D) k-means clustering of FGFR1, PARP1, ALDH1A1, ABCB1, RAD51, and H2AFX mRNA in the provisional TCGA pancreatic adenocarcinoma cohort. (E) Gene-set expression-based cohort stratification into therapy responders and non-responders using the E-GEOD-17891, AFFY_HG_U133_PLUS_2 dataset (n = 47). Clustering was based on correlation distance and average linkage. Unit variance scaling is applied to rows; Singular-value decomposition with imputation was used for principal component (PC) calculation. X and Y axes show PC 1 and PC 2, which explain 43.3% and 18.2% of the total variance, respectively. Missense (VUS): Missense variants of uncertain significance