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Isobolographic analysis of the cytotoxicity produced by doxorubicin in combination with β-caryophyllene at the chemosensitizing concentrations of 50 µM in Mz-ChA-1 cholangiocarcinoma cells. (A) Long-term exposure of 24 h and 72 h. (B) Single and double repeated metronomic exposure of 2 h.
