Table 5. IC₅₀ Values of the Compounds 3b, 5a, 5b, 11a, and 11b on the DHPS and DHFR Enzymes Using SD and TMP as Reference Drugs.

compd no.	IC50a (DHPS, μg/mL)	IC50a (DHFR, μg/mL)
3b	6.90 ± 0.44	0.37 ± 0.009
5a	14.65 ± 0.96	0.26 ± 0.009
5b	13.15 ± 0.74	0.30 ± 0.011
11a	2.76 ± 0.16	0.20 ± 0.007
11b	10.46 ± 0.07	5.52 ± 0.070
SD	2.05 ± 0.12	NT
TMP	NT	0.17 ± 0.005

^aThe data are expressed as the mean ± SD of three independent experiments.