(a) Plots of the measured
chemical shift perturbations of the amide
protons and nitrogens of NDM-1, in the presence of 2 molar equiv of
Zn(II), after addition of 2 molar equiv of flavonols: (a1) quercetin,
(a2) myricetin, and (a3) morin. (b) Plots of the measured chemical
shift perturbations of the amide protons and nitrogens of NDM-1, in
the absence of Zn(II) and 2 molar equiv of morin (b1) and 4 molar
equiv of morin (b2). In red, orange, and yellow are represented the
residues with Δδ > 0.09 ppm, 0.09 > Δδ
> 0.05
ppm, and Δδ > 0.02 ppm, respectively. The unassigned
residues
of NDM-1 are represented by gray lines.