Figure 8.

A Proposed Model of the Mechanism by Which Allicin Regulates Mitochondrial Homeostasis in Brown Adipocytes

Allicin promotes the phosphorylation of sirt1 and then activates the PGC1α-Tfam pathway, thereby increasing mitochondrial biogenesis and resulting in increased thermogenesis and fatty acid oxidation. However, allicin treatment at high doses could induce mitophagy due to the increase in succinylation in the mitochondria of brown adipocytes due to the inhibition of sirt5, resulting in mitochondrial dysfunction. These results indicate that allicin plays dual roles, similar to yin and yang properties.