Figure 3.

Enhancement of TAA-derived peptide-specific T-cell responses after RFA with DC (A) and OK432-DC (B) injections. Magnitude of TAA-specific T-cell responses was examined by IFN-γ ELISPOT assay. The frequency of T cells responsive to each peptide before RFA (the number of left side) and after RFA with DC injection (the number of right side) is shown. Responses to peptides were considered positive (gray boxes) if equal and more than 10 specific spots per 300,000 PBMCs were detected and if the numbers of spots after RFA with DC injection were at least two-fold that before. Boxes: patients with significantly increased TAA-specific T-cell responses.