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. 2020 May 14;18:201. doi: 10.1186/s12967-020-02366-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Identification and biological function of hypoxia-immune-related protective and risk DEGs. a Kaplan–Meier plot of overall survival for patients in three groups by combining the hypoxia and immune status. b Heatmap showing expression profiles for hypoxia-immune-related DEGs with comparison between hypoxia^low/immune^high and hypoxia^high/immune^low groups. c, d Venn diagrams show overlaps of hypoxia-immune-related DEGs with hypoxia-related and immune-related DEGs for identification of protective and risk DEGs. e, f Representative Gene Ontology terms enriched by the hypoxia-immune-related protective and risk DEGs. P-values were adjusted by false discovery rate