Table 3.

Multivariate Cox regression analyses of risk factors for overall survival

	Adjusted Hazard ratioa	95% confidence interval	Adjusted p
Discovery cohort
Risk group (High vs low)	3.24	2.03–5.18	< 0.001
Tumor stage			< 0.001
II vs I	1.35	0.48–3.81	0.574
III vs I	3.37	1.24–9.17	0.017
TCGA cohort
Risk group (High vs low)	2.91	1.76–4.80	< 0.001
Tumor stage			< 0.001
II vs I	1.91	0.93–3.92	0.076
III vs I	3.04	1.54–6.01	0.001
VI vs I	6.92	3.07–15.59	< 0.001
ACRG cohort
Risk group (High vs low)	1.99	1.42–2.78	< 0.001
Tumor stage			< 0.001
II vs I	1.51	0.58–3.93	0.398
III vs I	3.01	1.18–7.68	0.021
VI vs I	8.83	3.50–22.28	< 0.001
CHEM cohort
Risk group (High vs low)	3.01	1.56–5.83	0.001
Tumor stage			0.012
III vs II	2.20	1.04–4.64	0.039
IV vs II	3.35	1.50–7.48	0.003

^aGender and age were adjusted for modelling using the discovery cohort; and gender, age and histology classification were adjusted when using TCGA, ACRG and CHEM cohorts