Table 1.

Mechanisms and Effects of PI3K-AKT activation.

	Mechanism of PI3K-AKT Activation	Effects of PI3K-AKT Activation on
		Metabolism	Autophagy	Apoptosis	Trafficking RC
SFV	Strong activation via YXXM motif in nsP3	Increases glycolysis and fatty acid synthesis	Blocks degradation of autophagosomes	Small, not significant delay	RCs traffic from PM to CPV-I
RRV	Strong activation via YXXM motif in nsP3	Increases fatty acid synthesis	Unknown	Small, not significant delay	RCs traffic from PM to CPV-I
CHIKV	Moderate activation by unknown mechanism	Unknown	Increases production of autophagosomes	Unknown	RC mostly remain at PM
SINV	Weak or transient activation by unknown mechanism	Unknown	Unknown	Unknown	RC mostly remain at PM