Table 3.
Genes highly modulated by B4GALNT2 in LS174T cells.
| Gene Symbol | Expression | Fold Change S2/S11 Vs. Neo | p-Value S2/S11 Vs. Neo | Gene Name | Function in Cancer | PMID | ||
|---|---|---|---|---|---|---|---|---|
| Neo | S2/S11 | |||||||
| CD200 | 2 | 27.0 | 16.8 | 0.0411 | CD200 molecule | Possible colon cancer stem cell marker | 27574016 | |
| NGFRAP1 | 39 | 456.3 | 11.6 | 0.0383 | Nerve growth factor receptor (TNFRSF16) associated protein 1 | Overexpression inhibits growth of breast tumor xenografts. | 26408910 | |
| SKAP1 | 138 | 912.3 | 6.6 | 0.0231 | Src kinase associated phosphoprotein 1 | Modulates TCR signaling. | 18320039 | |
| SLC14A1 | 2 | 10.8 | 5.2 | 0.0360 | Solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | Potential tumor suppressor in lung cancer | 22223368 | |
| FAM26F | 8 | 2.0 | −4.1 | 0.0195 | Family with sequence similarity 26, member F | Little or no information | ||
| FAM110B | 9 | 2.1 | −4.5 | 0.0142 | Family with sequence similarity 110, member B | Promotes growth of prostate cancer cells | 21919029 | |
| ALX1 | 12 | 2.6 | −4.6 | 0.0167 | ALX homeobox 1 | Promotes EMT and invasion in ovarian and lung cancer. | 26722397 23288509 | |
| F5 | 12 | 2.6 | −4.7 | 0.0331 | Coagulation factor V (proaccelerin, labile factor) | Little or no information | ||
| INMT | 9 | 1.8 | −4.7 | 0.0142 | Indolethylamine N-methyltransferase | Negatively associated with prostate cancer progression | 22075945 | |
| MYH3 | 1198 | 238.9 | −5.0 | 0.0167 | Myosin, heavy chain 3, skeletal muscle, embryonic | Little or no information | ||
| MBOAT2 | 14 | 2.5 | −5.4 | 0.0383 | Membrane bound O-acyltransferase domain containing 2 | Little or no information | ||
| ROR1 | 12 | 1.8 | −6.4 | 0.0163 | Receptor tyrosine kinase-like orphan receptor 1 | Associated with ovarian cancer stem cells | 25411317 | |
| RAI14 | 51 | 7.7 | −6.6 | 0.0190 | Retinoic acid induced 14 | Overexpressed in gastric cancer, associated with worse prognosis. | 29654694 | |
| FMO3 | 14 | 1.8 | −7.7 | 0.0253 | Flavin containing monooxygenase 3 | Involved in de-toxification of drugs. | 16800822 | |
| PEG10 | 44 | 5.3 | −8.4 | 0.0233 | Paternally expressed 10 | Enhances cell invasion by upregulating β-catenin, MMP-2 and MMP-9 | 25199998 | |
| NINL | 244 | 28.4 | −8.6 | 0.0339 | Ninein-like | High expression associates with poor prognosis in prostate cancer | 30637711 | |
| ARMC4 | 15 | 1.7 | −8.7 | 0.0196 | Armadillo repeat containing 4 | Can be mutated in gastric cancer. | 26330360 | |
| MID2 | 32 | 2.1 | −15.0 | 0.0152 | Midline 2 | In breast cancer associates with BRCA1 and promotes growth. | 26791755 | |
| SOX2 | 28 | 1.7 | −16.5 | 0.0163 | SRY (sex determining region Y)-box 2 | Associated with motility and a cancer stem cell phenotype in CRC | 29228716 30518951 | |
| LGALS2 | 362 | 21.5 | −16.8 | 0.0142 | Lectin, galactoside-binding, soluble, 2 | Elevated in plasma of CRC patients. Promotes adhesion to endothelia. | 21933892 | |
| NPTX1 | 42 | 2.4 | −17.3 | 0.0123 | Neuronal pentraxin I | Anti proliferative in colon cancer | 29345391 | |
| GALC | 49 | 2.0 | −24.9 | 0.0077 | Galactosylceramidase | Unclear | ||
| STARD3NL | 98 | 3.6 | −27.4 | 0.0346 | STARD3 N-terminal like | Little or no information | ||
| ZNF22 | 83 | 1.9 | −44.6 | 0.0077 | Zinc finger protein 22 | Little or no information | ||
| NID1 | 459 | 5.1 | −89.4 | 0.0306 | nidogen 1 | Promotes EMT and metastasis in ovarian, breast and lung cancer. | 28416770 28827399 | |
The corrected p-value was calculated using the multiple test correction Benjamini–Hochberg. p < 0.05, fold change mean S2/S11 B4GALNT2 vs. Neo ≥ 4. The red line separates up-regulated genes from down-regulated genes. The violet or yellow labels indicate putative tumor-promoting or tumor-restraining changes, respectively.