Table 6.
Gene expression comparison between TCGA cohort (Non- and High B4GALNT2 expressers and microarray analyisis of LS174T cells (modulated by 3D only in S2/S11).
| Gene Name | Non-B4GALNT2 Expressers | High B4GALNT2 Expressers | Consistency | p-Value | |
|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | ||||
| Cytoskeleton and mitosis | KIZ (PLK1S1) | 346 ± 302 | 250 ± 154 | Yes | ≤0.01 |
| CEP120 | 404 ± 116 | 340 ± 135 | Yes | ≤0.01 | |
| DNAH6 | 33 ± 28 | 27 ± 15 | Yes | ≤0.05 | |
| SGOL2 | 316 ± 124 | 273 ± 138 | Yes | ≤0.01 | |
| STARD13 | 529 ± 271 | 355 ± 211 | Yes | ≤0.01 | |
| Cell signaling | UPK1A | 16 ± 112 | 5 ± 21 | Yes | N.S. |
| Apoptosis | TNFAIP8L2 | 46 ± 38 | 58 ± 42 | Yes | ≤0.05 |
| PPM1K | 97 ± 133 | 10 ± 45 | No | ||
| SDPR | 186 ± 271 | 153 ± 162 | Yes | N.S | |
| Transcription regulation | PHF20L1 | 941 ± 296 | 794 ± 349 | Yes | ≤0.01 |
| KLF12 | 239 ± 199 | 179 ± 128 | Yes | ≤0.01 | |
| PCF11 | 1025 ± 302 | 856 ± 227 | Yes | ≤0.01 | |
| Immunity and inflammation | CTLA4 | 47 ± 85 | 42 ± 34 | No | |
| IL1A | 34 ± 86 | 69 ± 215 | Yes | ≤0.05 | |
| TDO2 | 232 ± 885 | 115 ± 156 | No |
The mean level of expression in TCGA database of genes selectively modulated by 3D growth only in S2/S11 cells (Table 5) was compared in the cohorts of non-B4GALNT2 expressers and of high B4GALNT2 expressers as in Table 4. The column “Consistency” indicates whether the difference observed in the cohorts was consistent with that reported in Table 5. Genes showing statistically significant consistent difference are indicated in bold (p ≤ 0.05 Student’s t test for independent samples). N.S. = non-significant. A few genes present in Table 5 are not present in this Table because they were not present in TCGA or not expressed.