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. 2020 Apr 16;9(4):989. doi: 10.3390/cells9040989

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Decrease of BMAL1 is clinically related to poor prognoses in breast cancer patients. (a,b) BMAL1 (a) and LDH-A (b) mRNA expression in normal and cancer breast tissue samples from GSE536 and GSE3744 database sets. N: normal breast tissue T: breast cancer tissue. (c,d) Relapse-free survival (RFS) analysis of BMAL1 (c) and LDH-A (d) low and high breast cancer patients on the Kaplan–Meier plotter database. (p: log-rank, HR: hazard ratio). (e) Graphical summarization: tumor acidosis-mediated decrease of BMAL1 via inhibition of transcription activity and protein stability promotes metastatic potency, which could be prevented by melatonin that inhibits hypoxia-induced LDH-A in breast cancer.