ACT/CS1	atypical cartilaginous tumour/chondrosarcoma grade 1
ACVR2A-FN	activin receptor 2A- fibronectin
AKT	Serine/Threonine Kinase+
APC	APC regulator of WNT signaling pathway
APCDD1	APC down-regulated 1
Bcl-2	Apoptosis Regulator
BET	the bromodomain and extra terminal domain
BRCA1	breast related cancer antigen 1
BRCA2	breast related cancer antigen 2
CD99	CD99 Molecule (XgBloodGroup)
CDK4	cyclin-dependent kinase 4
CDK4/6	cyclin-dependent kinase 4/6
CDKN2A	cyclin-dependent kinase Inhibitor 2A
CR	complete response
DAPK1	death-associated protein kinase 1
DNA/RNA	DeoxyriboNucleic Acid/RiboNucleic Acid
DNMTs	DNA methyltransferases
EGFR	epidermal growth factor receptor
ERCC1	excision repair cross-complementation group 1
ERCC2	excision repair cross-complementation group 2
ERG	ETS transcription factor ERG
ETS	proto-oncogene 1, transcription factor 1
ETV1	ETS Variant Transcription Factor 1
ETV4	ETS Variant Transcription Factor 4
EWS-FLI	Ewing Sarcoma-Friend Leukemia Insertion
EWS	Ewing Sarcoma
EWSR1	Ewing sarcoma breakpoint region 1, EWS RNA Binding Protein 1
EWSR1–FLI1	Ewing sarcoma breakpoint region 1 (EWS RNA Binding Protein 1) - Friend Leukemia Insertion
EXT	exostosin glycosyltransferase
EZH2	enhancer of zeste homolog 2
FEV	FEV Transcription Factor, ETS Family Member
FUS	FUS RNA Binding Protein
GD2	disialoganglioside 2
HDAC	histone deacetylase
HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1
HGOS	High-grade osteosarcoma
HIC1	HIC ZBTB transcriptional repressor 1
HSPGs	heparan sulphate proteoglycans
ICB	immune checkpoint blockade
IDH	isocitrate dehydrogenase genes
IGF-1	Insulin-like growth factor 1
IGF-1R	Insulin-like growth factor 1 receptor
IGF-2	Insulin-like growth factor 2
IGF	Insulin-like growth factor
IGF-2BP3	Insulin-like growth factor 2 - mRNA-binding protein 3
IHH	Indian Hedgehog Signaling Molecule
INFORM	individualized therapy for relapsed malignancies in childhood
IRF2BP2-CDX1	Interferon Regulatory Factor 2 Binding Protein 2-Caudal Type Homeobox 1
ISG	Italian Sarcoma Group
KDR	kinase insert domain receptor
KIT	Proto-Oncogene, Receptor Tyrosine Kinase
lncRNA	Long non-coding RNA
lncRNAs	long non-coding RNAs
LSAMP	Limbic System-Associated Membrane Protein
LSD1	Lysine Demethylase 1°
MDM2	MDM2 Proto-Oncogene
MGMT	O-6-methylguanine DNA methyltransferase
miRNA	microRNA
miRNAs	microRNAs
MSH2	mut S homolog 2
MTHFR	5,10-methylenetetrahydrofolate reductase
mTOR	mammalian target of rapamycin
NADPH	reduced nicotinamide adenine dinucleotide phosphate
NCOA2	Nuclear Receptor Coactivator 2
NER	Nucleotide excision repair
NGS	Next-generation sequencing
NRAS	NRAS Proto-Oncogene
p16	also known as p16INK4a, cyclin-dependent kinase inhibitor 2A or CDKN2A, multiple tumor suppressor 1
PALB2	partner and localizer of BRCA2
PARP	poly (ADP-ribose) polymerase
PD-1	programmedcelldeath 1
PD-L1	programmed death-ligand 1
PI3K/mTOR	phosphatidylinositol 3-kinase/mammalian target of rapamycin
PR	partial response
RASSF1A	Ras association domain family 1A
RB1	RB TranscriptionalCorepressor 1
RECQL	RecQ-like helicase
RHA	RNA helicase A
SAHA	suberoylanilide hydroxamic acid
SNP	Single nucleotide polymorphism
SQSTM1	Sequestosome 1
SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase
STAG2	Stromal Antigen 2
SV	structural variations
TAF15	TATA-Box Binding Protein Associated Factor 15
TARGET	Generate Effective Treatments Osteosarcoma project
TET	Tet Methylcytosine Dioxygenase
TGFβ	transforming growth factor β
TIMP3	TIMP metallopeptidase inhibitor 3
TMB	tumor mutational burden
TP53	Tumor Protein P53
WWOX	WW Domain ContainingOxidoreductase
α-KG	α-ketoglutarate
2-HG	2-hydroxyglutarate