Figure 5.

BRD4 inhibition protects against caerulein- and ethanol plus POA-induced pancreatitis in vivo. (A) Representative H&E images of pancreatic sections in CER and ethanol plus POA-induced pancreatitis (200×) (n = 5). (B) Histopathological scores for edema, inflammation, necrosis, and the total histology score (n = 5). (C) Representative micrographs of leukocyte marker CD45 immunohistochemical staining for the pancreas (200×). (D) mRNA levels of Tnf, Il1b, and Il6 from pancreatic tissue (n = 3) and serum amylase levels (n = 5). Scale bar = 100 μm. Data represent the mean values ± SEM. Statistical analysis was performed by Student’s un-paired, two-tailed t-test between two groups, *P < 0.05, compared to the control; #P < 0.05, compared to AP group.