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Schematic diagram for the mechanism of BRD4 inhibition on impaired autophagy during acute pancreatitis. BRD4 inhibition protects against pancreatic injury in the in vitro and in vivo settings of AP. Inhibition or knockdown of BRD4 upregulated SIRT1, leading to enhanced autophagosome fusion with lysosome and lysosomal degradation, therefore restored impaired autophagic flux by pancreatitis insults.
