Figure 4.

Protein expression of (A) adenosine triphosphate 5A (ATP5A), (B) nicotinamide adenine dinucleotide reduced form (NADH):ubiquinone oxidoreductase subunit S3 (NDUFS3), and (C) succinate dehydrogenase complex iron sulfur subunit (SDHB) in purified small extracellular vesicles (sEVs) from non-physically frail non-sarcopenic (non-PF&S) controls (n = 10) and participants with physical frailty and sarcopenia (PF&S; n = 11). Data were normalized for the amount of sEV total proteins and are shown as percentage of the control group set at 100%. Bars represent mean values (±standard error of the mean). * p < 0.0001 versus non-PF&S.