Table 1.
Betweenness centrality (BC) score and Bridges number identified based on STRING Interactome network analysis by Igrapg R and Fold Changes (FC) identified by DESeq in R of the differentially expressed genes DN vs. SC comparison. Average FC when two data were considered (Groups 1 and 2 respectively), n = 9 donors.
| Group | Gene | BC Score | Bridges | FC | Gene Description |
|---|---|---|---|---|---|
| 1 | ESR1 | 1445 | 3 | 2.0 | estrogen receptor 1 |
| UCP1 | 1323 | 1 | 6.1 | uncoupling protein 1 (mitochondrial, proton carrier) | |
| MT2A | 1061 | 2 | 2.4 | metallothionein 2A | |
| LEPR | 988 | 1 | 1.9 | leptin receptor | |
| IFIH1 | 957 | 0 | 2.0 | interferon induced with helicase C domain 1 | |
| IRF7 | 880 | 2 | 2.0 | interferon regulatory factor 7 | |
| NLRC4 | 864 | 1 | 1.9 | NLR family, CARD domain containing 4 | |
| CTSL | 813 | 1 | 1.9 | cathepsin L | |
| AGT | 745 | 2 | 2.4 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | |
| MAPK10 | 720 | 2 | 1.8 | mitogen-activated protein kinase 10 | |
| 2 | BMP4 | 2776 | 8 | 3.1 | bone morphogenetic protein 4 |
| CD34 | 2048 | 3 | 3.6 | stem cell adhesion | |
| EFNA5 | 1519 | 1 | 2.2 | ephrin-A5 | |
| RARB | 1362 | 0 | 3.9 | retinoic acid receptor, beta | |
| ALDH1A3 | 1194 | 1 | 4.4 | aldehyde dehydrogenase 1 family, member A3 | |
| SMOC1 | 1138 | 1 | 3.2 | SPARC related modular calcium binding 1 | |
| TBX1 | 1125 | 3 | 2.5 | T-box 1 | |
| RELN | 1087 | 0 | 3.1 | reelin | |
| SEMA3B | 1050 | 1 | 2.2 | immunoglobulin domain (semaphorin) short basic domain, secreted, 3B | |
| SPTA1 | 1046 | 1 | 2.1 | spectrin, alpha, erythrocytic 1 (elliptocytosis 2) |