Table 1. Identification of Potential Biomarkers^c,d.

no.	retention time (min)	mass-to-charge ratio	type	identified compound	comparison between groups (fold change)
1	0.79	182.0467	[M – H]−	4-pyridoxic acida	Con/EW (2.8)
2	0.84	204.0638	[M + Na]+	l-tyrosinea,b	Con/FW (<1)
3	1.28	204.0310	[M – H]−	xanthurenic acida	Con/EW (3.5)
4	1.58	188.0362	[M – H]−	kynurenic acida,b	Con/EW (3.1)
5	1.70	163.0405	[M – H]−	phenylpyruvic acida	Con/FW (<1)
6	1.85	188.0688	[M + Na]+	l-phenylalaninea,b	Con/FW (<1)
7	2.97	187.0075	[M – H]−	p-cresol sulfatea	Con/FW (2.8), Con/EW (4.0)
8	3.37	165.0564	[M – H]−	phenyllactic acida	Con/EW (6.2)
9	8.33	391.2852	[M + H]+	12-ketodeoxycholic acida	Con/EW (<1)
10	8.44	655.2765	[M + H]+	coproporphyrin IIIa	Con/EW (<1)
11	11.65	391.2875	[M – H]−	chenodeoxycholic acida,b	Con/EW (<1)
12	11.92	391.2868	[M – H]−	deoxycholic acida,b	Con/EW (<1)

^aMetabolites confirmed by literature or database searches and mass spectrometry (MS) fragmentation.

^bMetabolites confirmed using standard compounds.

^cCon-FW: significant differences in metabolites with p < 0.05 between the control and PM group I (4 weeks).

^dCon-EW: significant differences in metabolites with p < 0.05 between the control and PM group II (8 weeks).