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. 2019 Dec 19;17(2):147–156. doi: 10.1177/1740774519890146

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Example of an S-shaped dose-toxicity curve (left) and the corresponding straight line after transformation (right). The dotted horizontal line indates a target toxicity level of 0.3, or log(0.3/0.7) = –0.847 on the logit scale. P(DLT): probability of a dose-limiting toxicity.